A new study quantifying the global burden of tuberculosis among children suggests there are tens of millions of children with undiagnosed TB.
By Francesca Davenport
Researchers at the University of Sheffield, Imperial College London, and TB Alliance found evidence that there is a large gap between the number of recorded TB cases and the true incidence. The study, published today in Lancet Global Health, shows that TB in children is a major public health problem worldwide.
The investigators estimated the number of children with TB in the 22 countries with the highest burden of TB in the world using a mechanistic mathematical model. In contrast with standard estimates that are reliant on paediatric case reporting, which varies widely between countries, the researchers took a complementary approach, using mathematical modelling to estimate rates of infection and disease in children based on country-